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When the needs of either or both of the partners are not being met, the relationship is in trouble. This is not to say that people only think about the benefits they are getting; they will also consider the needs of the other. Although sexual arousal and excitement are more important early on in relationships, intimacy is also determined by sexual and romantic attraction. People are happy, healthy, and likely to stay in relationships in which they are sure that they can trust the other person to understand, validate, and care for them. It is this unconditional giving and receiving of love that promotes the welfare of both partners and provides the secure base that allows both partners to thrive. If Frank hits Joe, we might wonder if Frank is naturally aggressive or if perhaps Joe had provoked him. If Leslie leaves a big tip for the waitress, we might wonder if she is a generous person or if the service was particularly excellent. We carefully observe the people we are interested in and note how they behave in different social situations. Sometimes we may decide that the behavior was caused primarily by the person; this is called making a person attribution. At other times, we may determine that the behavior was caused primarily by the situation; this is called making a situation attribution. And at other times we may decide that the behavior was caused by both the person and the situation. It is easier to make personal attributions when behavior is more unusual or unexpected. Imagine, however, that instead of shaking your hand, Tess sticks out her tongue at you and walks away. I think you would agree that it is easier in this case to infer that Tess is unfriendly because her behavior is so contrary to [47] what one would expect (Jones, Davis, & Gergen, 1961). One error that we frequently make when making judgments about ourselves is to make self-serving attributions by judging the causes of our own behaviors in overly positive ways. Although making causal attributions is expected to be logical and scientific, our emotions are not irrelevant. Another way that our attributions are often inaccurate is that we are, by and large, too quick to attribute the behavior of other people to something personal about them rather than to something about their situation. The fundamental attribution error occurs in part because other people are so salient in our social environments. When I look at you, I see you as my focus, and so I am likely to make personal attributions about you. If the situation is reversed such that people see situations from the [49] perspectives of others, the fundamental attribution error is reduced (Storms, 1973). An important moral about perceiving others applies here: We should not be too quick to judge other people. It is easy to think that poor people are lazy, that people who say something harsh are rude or unfriendly, and that all terrorists are insane madmen. But these attributions may frequently overemphasize the role of the person, resulting in an inappropriate and inaccurate [51] tendency to blame the victim (Lerner, 1980; Tennen & Affleck, 1990). Sometimes people are lazy and rude, and some terrorists are probably insane, but these people may also be influenced by the situation in which they find themselves. When you find yourself making strong person attributions for the behaviors of others, I hope you will stop and think more carefully. Would you want other people to make person attributions for your behavior in the same situation, or would you prefer that they more fully consider the situation surrounding your behavior. Attitudes and Behavior Attitude refer to our relatively enduring evaluations of people and things(Albarracin, Johnson, & Zanna, [52] 2005). We each hold many thousands of attitudes, including those about family and friends, political parties and political figures, abortion rights, preferences for music, and much more. Some of our attitudes, including those about sports, roller coaster rides, and capital punishment, are heritable, which explains in part why we are similar to our parents on many dimensions [53] (Olson, Vernon, Harris, & Jang, 2001). Other attitudes are learned through direct and indirect [54] experiences with the attitude objects (De Houwer, Thomas, & Baeyens, 2001). If we know that a person has a more positive attitude toward Frosted Flakes than toward Cheerios, then we will naturally predict that she will buy more of the former when she gets to the market. If we know that Charlie is madly in love with Charlene, then we will not be surprised when he proposes marriage. Because attitudes often predict behavior, people who wish to change behavior frequently try to change attitudes through the use of persuasive communications. If the listener wants to be entertained, then it is better to use a humorous ad; if the listener Consider the goals of the listener. Try to associate your product with positive stimuli such as funny jokes or attractive Use classical conditioning. Behaviors are more likely to be consistent with attitudes when the social situation in which the behavior occurs is similar to [57] the situation in which the attitude is expressed (Ajzen, 1991). Although it might not have surprised you to hear that our attitudes predict our behaviors, you might be more surprised to learn that our behaviors also have an influence on our attitudes. Self perception occurs when we use our own behavior as a guide to help us determine our own [58] thoughts and feelings (Bem, 1972; Olson & Stone, 2005). In one demonstration of the power [59] of self-perception, Wells and Petty (1980) assigned their research participants to shake their heads either up and down or side to side as they read newspaper editorials. The participants who had shaken their heads up and down later agreed with the content of the editorials more than the people who had shaken them side to side. Wells and Petty argued that this occurred because the participants used their own head-shaking behaviors to determine their attitudes about the editorials. Thefoot-in-the-door technique is a method of persuasion in which the person is first persuaded to accept a rather minor request and then asked for a larger one after that. The idea is that when asked the second time, the people looked at their past behavior (having agreed to the small request) and inferred that they are helpful people.

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There are notable exceptions, however, such as the parasitic castration of Crustacea already mentioned. My third dimension of classification of host-parasite relations concerns the continuum from what may be called close intimacy to action at a distance. All genes exert power primarily by serving as templates for the synthesis of proteins. The locus of primary gene power is, therefore, the cell, in particular the cytoplasm surrounding the nucleus in which the gene sits. The phenotypic expression of a gene is then, in the first place, its influence on cytoplasmic biochemistry. In its turn, this influences the form and structure of the whole cell, and the nature of its chemical and physical interactions with neighbouring cells. This affects the build-up of multicellular tissues, and in turn the differentiation of a variety of tissues in the developing body. Finally emerge the attributes of the whole organism that gross anatomists and ethologists identify at their level as phenotypic expressions of genes. Where parasite genes exert shared power with host genes over the same host phenotypic characteristic, the confluence of the two powers may occur 226 Host Phenotypes of Parasite Genes at any stage in the chain just described. Snail genes, and the genes of the fluke that parasitizes the snail, exert their power separately from each other at the cellular and even the tissue level. They influence the cytoplasmic chemistry of their respective cells separately, because they do not share cells. They influence tissue formation separately, because snail tissues are not intimately infiltrated by fluke tissues in the way that, say, the algal and fungal tissues of a lichen are intimate. Snail genes and fluke genes influence the development of organ systems, indeed of whole organisms, separately, because all the fluke cells are gathered together in one mass rather than being interspersed among snail cells. If fluke genes influence snail shell thickness, they do so by first collaborating with other fluke genes to make a whole fluke. Whether they conflict or cooperate will depend not on their historical origins but on the circumstances from which they stand to gain now. They are therefore in a position to influence the cellular chemistry of the host at an intimate level, if not quite such an intimate level as an insertion sequence in the host chromosome. Intracellular parasites in the cytoplasm, too, may be presumed to be in a position to exert considerable power over host phenotypes. Some parasites do not infiltrate the host at the cellular level, but at the tissue level. The separate cells of parasitic bacteria and protozoa may infiltrate the host tissues with similarly comprehensive intimacy. Other internal parasites, such as the flukes we have been discussing, do not mix their tissues with those of the host, but keep their tissues to themselves and exert power only at the level of the whole organism. Both are whole-organism parasites rather than tissue parasites Host Phenotypes of Parasite Genes 227 or cell parasites. The difference is a practical one, and a rather smaller one than the difference between, say, a cellular parasite and a tissue parasite. It has to rely on other media for its manipulation, for instance sound waves and light waves. Cuckoo genes, in exerting their developmental power over host phenotypes, have to rely on action at a distance. The concept of genetic action at a distance pushes our idea of the extended phenotype out to its logical culmination. Usually all individuals in one species coil the same way, but a few polymorphic species are to be found. In the Pacific island land snail Partula suturalis some local populations are right-handed, others are left-handed, and others are mixed in various proportions. It is therefore possible to study the genetics of directionality of coiling (Murray & Clarke 1966). But when Murray and Clarke crossed F1 snails with each other they obtained a curious result. All the progeny were left-handed, regardless of the direction of coiling of either parent. The underlying genotypes of the F2 generation presumably segregated in classic 3:1 Mendelian fashion, but this did not show itself in their phenotypes. The F1 individuals themselves were left-handed or right-handed in equal proportion, yet all had the same heterozygous genotype, and all therefore produced left-handed offspring. A similar effect had been obtained earlier in the freshwater snail Limnaea peregra, though in that case right-handedness was dominant. It illustrates, in a particularly clear and simple manner, that the power of a gene may extend beyond the boundaries of the body in whose cells it sits (Haldane 1932b). We cannot hope that all genetic action at a distance will reveal itself in so elegant a Mendelian manner as in the case of the snails. Again as in conventional genetics, we do not necessarily have to do genetic experiments in order to infer the presence of genetic influence on variation. Once we have satisfied ourselves that a given characteristic is a Darwinian adaptation this, in itself, is tantamount to satisfying ourselves that variation in that character must at one time have had a genetic basis. If it had not, selection could not have preserved the advantageous adaptation in the population. A female mouse who has just been inseminated by one male has her pregnancy blocked by exposure to chemical influence from a second male. The effect seems also to occur in a variety of species of mice and voles in nature. I have expressed the hypothesis in the language of Chapter 4, the language of individual manipulation. But it can equally well be expressed in the language of the extended phenotype and genetic action at a distance. Genes 230 Action at a Distance in male mice have phenotypic expression in female bodies, in just the same sense as genes in mother snails have phenotypic expression in the bodies of their children. A mutant gene arose which, when present in the body of a male mouse, had phenotypic expression in the bodies of female mice with whom he came in contact. The route of action of the gene on its final phenotype was long and complex, but not noticeably more so than routes of genetic action within bodies customarily are. In conventional within-body genetics, the chain of causation leading from gene to observed phenotype may have many links. A biochemist may detect the phenotype that interests him at this second link stage. Physiologists or anatomists will not pick up the phenotype that interests them until more stages have been passed. They will not concern themselves with the details of these earlier links in the chain, but will take them for granted. Whole-organism geneticists find it sufficient to do breeding experiments looking only at what, for them, is the final link in the chain, eye colour, crinkliness of hair, or whatever it is. He arbitrarily chooses to regard a behaviour pattern as the end link in the chain, but he knows that the abnormal behaviour of a mutant is caused by, say, abnormal neuroanatomy, or abnormal endocrine physiology. He knows that he could have looked with a microscope at the nervous system in order to detect his mutants, but he preferred to look at behaviour instead (Brenner 1974). He made an arbitrary decision to regard observed behaviour as the end link in the chain of causation. So, a student of the genetics of the Bruce Effect could assay male pheromones biochemically in order to detect the variation upon which to base his genetic study. Or he could look further back in the chain, ultimately to the immediate polypeptide products of the genes concerned.

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Young Fay lives in the lighthouse on Breaksea Island, near the mouth of King George Sound and the town of Albany in Western Australia. He ends up in Gallipoli and we see some of that conflict through his brief correspondence before he dies of his wounds. John lives in two worlds, the public service world of Canberra and the country of his ancestors. He and Ros and their children journey regularly to his country where Ros builds close bonds with the Borroloola women of Law. Her desert journal chronicles a range of stories that give deep insight into the Aboriginal experience. The story is one of courage and care, and allows readers to experience the plight of these young refugees. While it is fiction, parallels can certainly be drawn with the many refugees who have become part of Australian society. Little Tim stows away on a steamer and when he is discovered he is set to work scrubbing decks. When the boat sinks he has to return home but his parents are persuaded by the captain to allow him to become a sailor. This play deals sympathetically with awakening sexuality and school relationships. Lockie is growing up and family responsibilities take over when his mother suffers a breakdown and is admitted to the local hospital. This suspenseful verse novel explores, through dual narrative, the experience of two families bound together in a common quest. In searching for the wolf, an animal that both their fathers want dead for different reasons, Lucy and Jake forge a relationship leading to self awareness and discovery. The succinct text and wonderful illustrations will encourage the imaginations of the readers. This honest and insightful novel will provide many opportunities for classroom discussion and composing. The layout is different from a play with a great deal of the text dedicated to describing the setting and the actions in between the spoken text. In brackets there are statements of what actually happened in the film, showing that the film deviated slightly from the script. It can be studied alongside the film or before viewing the film to see what camera angles and sound one would add. The first film in the trilogy, the Fellowship of the Ring, won four academy awards and numerous other international and prestigious awards. An examination of the first film of the trilogy provides an understanding of the complexity of the world in which the action takes place as well as the narrative form and development. While elements of this film and story are dark and fearful, the overwhelming sense of loyalty, honour, rightness and heroism outbalances these. Worthwhile to study with Pride and Prejudice and explore the intertextuality of this series. Gathered from newspaper reports, retellings and eyewitness accounts of the time, we learn how three children managed to survive nine days in the Victorian outback after becoming lost. The ability of Aboriginal trackers to find their trail after almost all hope was lost is highlighted. The accompanying illustrations by artists of the time add to the historical perspective, as do the informative sections at the end of each chapter, which cover housing, food, transport, toys, schooling and clothing of the 1860s. Provides a model for retelling factual events in an interesting and more personal manner. A three-time paralympian, Sauvage has won titles in everything from the marathon to short sprints. She has gained an extraordinary number of medals and awards, including the 1999 Australian Female Athlete of the Year Award and an Order of Australia Medal. This account of her life and travels emphasises the dedication and determination necessary to achieve at the elite level in her sport. It combines stills, archival photographs and film with contemporary footage and studio interviews. This is an excellent film for studying the techniques of the political documentary. This is some of the most moving writing about loss and death from cancer, as well as some of the warmest and funniest on perennial teenage and family issues. Each book has a list of dramatis personae, and a prologue which gives an outline of the situation before the play starts. The books allows you to develop some interesting class activities on visual techniques, matching words to images, and revealing character through the visual. The film reveals the cultural diversity of New York City and how such a program can overcome the problems and prejudices that can result from such diversity. The shared goals and aspirations of the children involved unite them, and their love of the dance is infectious to the viewer as we watch them strive for achievement and get caught up in the sheer enjoyment of what they are doing. We share with them the excitement and energy of the final competition and it is difficult not to cheer on your favourites as they compete. Maisy travels on a train to a beach holiday and she meets all the usual characters from the Maisie series.

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Preterm rupture of membranes at 20 weeks or earlier is associated with a poor prognosis; about 40% miscarry within five days of membrane rupture due to chorioamnionitis and in the remaining 60% of pregnancies more than 50% of neonates die due to pulmonary hypoplasia. Uteroplacental insufficiency resulting in oligohydramnios at 18-23 weeks is very severe and the most likely outcome is intrauterine death. Prevalence Polyhydramnios in the second trimester is found in about 1 per 200 pregnancies. Etiology There are essentially two major causes of polyhydramnios; reduced fetal swallowing or absorption of amniotic fluid and increased fetal urination. Reduced fetal swallowing may be due to craniospinal defects (such as anencephaly), facial tumours, gastrointestinal obstruction (such as esophageal atresia, duodenal atresia and small bowel obstruction), compressive pulmonary disorders (such as pleural effusions, diaphragmatic hernia or cystic adenomatoid malformation of the lungs), narrow thoracic cage (due to skeletal dysplasias), and fetal akinesia deformation sequence (due to neuromascular impairement of fetal swallowing). Increased fetal urination is observed in maternal diabetes mellitus and maternal uremia (increased glucose and urea cause osmotic diuresis), hyperdynamic fetal circulation due to fetal anemia (due to red cell isoimmunization or congenital infection) or fetal and placental tumours or cutaneous arteriovenous malformations (such as sacrococcygeal teratoma, placental chorioangioma), or twin-to twin transfusion syndrome. Quantitatively, polyhydramnios is defined as an amniotic fluid index (the sum of the vertical measurements of the largest pockets of amniotic fluid in the four quadrants of the uterus) of 20 cm or more. Alternatively, the vertical measurement of the largest single pocket of amniotic fluid free of fetal parts is used to classify polyhydramnios into mild (8-11 cm), moderate (12-15 cm) and severe (16 cm or more). Although 80% of cases with mild polyhydramnios are considered to be idiopathic, in the majority of cases with moderate or severe polyhydramnios there are maternal or fetal disorders. In most cases polyhydramnios develops late in the second or in the third trimester of pregnancy. Acute polyhydramnios at 18-23 weeks is mainly seen in association with twin-to-twin transfusion syndrome. Testing for maternal diabetes, detailed sonographic examination for anomalies, and fetal karyotyping should constitute the cornerstones of the diagnostic protocol in the investigation of these cases. Moderate polyhydramnios Polyhydramnios Diaphragmatic Hernia Prenatal therapy the aim is to reduce the risk of very premature delivery and the maternal discomfort that often accompanies severe polyhydramnios. Treatment will obviously depend on the diagnosis, and will include better glycemic control of maternal diabetes mellitus, antiarrhythmic medication for fetal hydrops due to dysrrhythmias, thoracoamniotic shunting for fetal pulmonary cysts or pleural effusions. For the other cases, polyhydramnios may be treated by repeated amniocenteses every few days and drainage of large volumes of amniotic fluid. An alternative and effective method of treatment is maternal administration of indomethacin; however, this drug may cause fetal ductul constriction and close monitoring by serial fetal echocardiographic studies is necessary. In twin-to-twin transfusion syndrome, presenting with acute polyhydramnios at 18-23 weeks of gestation, endocopic laser occlusion of placental anastomoses or serial amniodrainage may be carried out. Ultrasound Obstet Gynecol 1999;13:167-70) Maternal age Gestational age (years) 10 weeks 12 weeks 14 weeks 16 weeks 20 weeks 40 weeks 20 1/983 1/1068 1/1140 1/1200 1/1295 1/1527 25 1/870 1/946 1/1009 1/1062 1/1147 1/1352 30 1/576 1/626 1/668 1/703 1/759 1/895 31 1/500 1/543 1/580 1/610 1/658 1/776 32 1/424 1/461 1/492 1/518 1/559 1/659 33 1/352 1/383 1/409 1/430 1/464 1/547 34 1/287 1/312 1/333 1/350 1/378 1/446 35 1/229 1/249 1/266 1/280 1/302 1/356 36 1/180 1/196 1/209 1/220 1/238 1/280 37 1/140 1/152 1/163 1/171 1/185 1/218 38 1/108 1/117 1/125 1/131 1/142 1/167 39 1/82 1/89 1/95 1/100 1/108 1/128 40 1/62 1/68 1/72 1/76 1/82 1/97 41 1/47 1/51 1/54 1/57 1/62 1/73 42 1/35 1/38 1/41 1/43 1/46 1/55 43 1/26 1/29 1/30 1/32 1/35 1/41 44 1/20 1/21 1/23 1/24 1/26 1/30 45 1/15 1/16 1/17 1/18 1/19 1/23 Table 2 Risk of trisomy 18 (Snijders et al. Va was the distance between the lateral wall of the anterior horn to the mid-line and Vp was the distance between the medial and lateral walls of the posterior horn. For each of the measurements and their ratios, regression analysis was applied examining linear, quadratic and cubic models for the association with gestational age (in days). For those measurements where the standard deviation increased or decreased with gestation, logarithmic or square root transformation was applied to stabilize variance. If the quadratic or cubic terms did not improve the original linear model (an independent correlation with p < 0. Where the quadratic or cubic components did improve the model, they were included in the equation for the regression line. To produce the reference ranges in the original units, the mean and limits of the calculated reference range in transformed units were subjected to anti-logarithmic or power transformation as appropriate. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission in writing of Oxford University Press, or as expressly permitted by law, by license, or under terms agreed with the appropriate reproduction rights organization. Inquiries concerning reproduction outside the scope of the above should be sent to the Rights Department, Oxford University Press, at the address above. You must not circulate this work in any other form and you must impose this same condition on any acquirer. Title: Ketogenic diet and metabolic therapies : expanded roles in health and disease / edited by Susan A. Description: Oxford; New York : Oxford University Press, [2017] | Includes bibliographical references and index. Treatment for the conditions described in this material is highly dependent on the individual circumstances. And, while this material is designed to ofer accurate information with respect to the subject matter covered and to be current as of the time it was written, research and knowledge about medical and health issues is constantly evolving and dose schedules for medications are being revised continually, with new side efects recognized and accounted for regularly. Readers must therefore always check the product information and clinical procedures with the most up-to-date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulation. The publisher and the authors make no representations or warranties to readers, express or implied, as to the accuracy or completeness of this material. Without limiting the foregoing, the publisher and the authors make no representations or warranties as to the accuracy or efcacy of the drug dosages mentioned in the material. The authors and the publisher do not accept, and expressly disclaim, any responsibility for any liability, loss or risk that may be claimed or incurred as a consequence of the use and/or application of any of the contents of this material. Metabolism-Based Treatments Demand, and Results 16 to Counter Cancer: Scientifc Rationale 79 Emily L. Ketogenic Diet in Established and Comorbidities 101 Epilepsy Indications 40 Ning Cheng, PhD, Susan A. Efects of the Ketogenic Diet on Laboratory: Progress on Models the Blood-Brain Barrier 289 and Mechanisms 165 Manoj Banjara, PhD and Detlev Boison, PhD Damir Janigro, PhD 20. Ketogenic Diet in a Hippocampal General Health and Metabolic Alternatives Slice: Models and Mechanisms 186 Dominic P. Understanding key mechanisms underlying lished in 1921 as an efective treatment for seizures the success of metabolic therapy is of the high in both children and adults, and it has been pre est biomedical signifcance: it is anticipated these scribed to a subset of patients with epilepsy ever mechanisms will apply to provide breakthroughs since. Today there are many drugs available to for multiple common, chronic, and poorly treated control epileptic seizures, yet this metabolic ther disorders. Similarly, a comprehensive understand apy can stop seizures even when all medications ing of the range and type of acute and chronic con fail: for some patients a ketogenic diet is superior ditions that metabolic therapies can prevent, delay, to all known drug treatments. Adhering to a medically prescribed disease and promote health by compiling the lat and carefully formulated high-fat ketogenic diet est research and perspectives of leading experts on can maintain the ketone-based metabolism used ketogenic diets and metabolic therapies. The last chapter is devoted to side efects and less likely to produce lasting two key organizations: the Charlie Foundation, changes. Evidence applications of ketogenic therapies throughout is also mounting that ketogenic diets can reverse the world. Together we look forward to the 100th diet, adenosine links metabolism and brain activ anniversary of the ketogenic diet in 2021 with ity and has been proven to have powerful anti optimism that metabolic therapies will ofer new, seizure, neuroprotective, and disease-modifying safe, and efective options to promote health and benefts. Danial, PhD Okayama, Japan Department of Cancer Biology Dana-Farber Cancer Institute Damir Janigro, PhD Department of Cell Biology Flocel, Inc. Robert Haslam Chair in Pediatric Neurology Departments of Medicine and Pharmacology Cumming School of Medicine, University and Physiology of Calgary Universite de Sherbrooke Calgary, Canada Sherbrooke, Quebec, Canada David N. Woolf, PhD Lab of Metabolic Control Neuro-Oncology Research National Institute of Alcohol Abuse and Barrow Brain Tumor Research Center Alcoholism Barrow Neurological Institute dba St. Russell Wilder at the Mayo Clinic, its ketogenic diet plus a daily supplement of either creation came at a time in which there were few saccharin (treatment group) or glucose (to pre other options for epilepsy (Wilder, 1921). Several of starting this treatment have led to widespread randomized controlled clinical trials, crossover availability, willingness of patients and neurolo studies, and prospective studies have confrmed gists to consider it in their treatment algorithm, a response rate of approximately 50% in children and better (and safer) outcomes.

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Tabak, Hungary 928 Dramatic reduction of costs with Diabgest, a telehealth platform for gestational diabetes J. Sallee, France 929 Demographic and clinical factors for safer pregnancy in diabetes: trends over time in a national primary care study M. Zapanti, Greece 932 Are there differences in maternal and neonatal outcomes among tight controlled pregnancies with gestational diabetes and the general population. Zoupas, Greece 225 933 Adaptive insulin secretion despite impaired islet cell proliferation in a pregnant mouse model with impaired glucose tolerance K. Scherneck, Germany 934 Gut microbiota changes are associated with insulin resistance in women with gestational diabetes D. Zgur-Bertok, Slovenia 935 Relative significance of fasting versus post-load glucose levels in pregnancy: a population-based study P. Bhattacharyya, India 939 Serum adipocyte fatty acid-binding protein levels are associated with rapid renal function decline in patients with type 2 diabetes S. Nam, Korea, Republic of 226 940 the relationship between telomere length and diabetic kidney disease: the Hong Kong Diabetes Register F. Schaper, Netherlands 944 Glucose-lowering agents and incidence of amputation in patients with type 2 diabetes: a systematic review and network meta-analysis E. Ejskjaer, Denmark 946 Prediction models for the risk of diabetic foot in people with type 2 diabetes: a systematic review and external validation study J. Hagen, Germany 949 the use of artificial neuronal network for three-month prognosis in individuals with diabetic foot syndrome A. Czupryniak, Poland 950 Long-term reduction of major amputations by two-thirds after implementation of a binding multidisciplinary treatment concept in a regular and emergency care hospital B. Piorkowski, Germany 951 Negative pressure wound therapy in diabetic foot wounds: a systematic review and meta-analysis of real world data P. Kevorkian, France 228 954 Effect of negative pressure wound therapy on the level of selected circulating signalling molecules in patients with diabetic foot ulcer S. Malecki, Poland 955 Monitoring wound healing of diabetic foot ulcers using two-dimensional and three-dimensional wound measurements L. Yderstr de, Denmark 956 Protein tyrosine phosphatase 1B inhibition plays a role in the macrophage phenotype under high glucose conditions: potential therapy for diabetic wound healing A. Dickson, Australia 958 Cytoprotective effect of interleukin 4 on fibroblasts in a 3D culture system comprising immune factors of patients with chronic diabetic foot ulcers M. Spallone, Italy 960 Autonomic neuropathy in type 1 diabetes: findings from the T1D Exchange K. Charles, Denmark 962 the association between pulse wave velocity, diurnal indices of blood pressure, some vasoactive peptides and cardiovascular autonomic neuropathy V. Serhiyenko, Ukraine 963 Cardiovascular autonomic neuropathy correlate with cardiac diastolic dysfunction in patients with type 2 diabetes J. Kim, Korea, Republic of 964 Relationship between heart rate variability indices and laboratory markers in type 1 diabetic adults using canonical correlation analysis K. Pertseva, Ukraine 965 Evaluation of effect of diabetes on intracardiac nervous system by means of laser microdissection M. Pandey, Czech Republic 966 the presence of cardiac autonomic neuropathy is associated with improved diabetic foot ulcer healing F. Cosson, France 969 Analysis of gastric emptying measurement in a large cohort of patients suspected of diabetic gastroparesis, comparison between type 1 and type 2 diabetic patients J. Spallone, Italy 971 Comparison between multifrequency vibrometry, neurothesiometer and nerve conduction studies in subjects with type 1 diabetes E. Fleming, Germany 974 Retinal neurodegeneration in pediatric patients with type 1 diabetes F. Frontoni, Italy 978 Neuropathy of the upper limb: an underestimated complication of diabetes Z. Kopf, Germany 979 Diabetic neuropathy impacts muscle strength measures in patients with type 2 diabetes: a controlled study B. Calders, Belgium 980 the effect of diabetic sensory peripheral neuropathy on mortality: a meta-analysis M. Tabak, Hungary 981 Early indication of diabetic neuropathy is associated with higher risk of subsequent cardiovascular disease in screen-detected type 2 diabetes L. Charles, Denmark 982 Type 2 diabetes patients with peripheral neuropathy display an increased risk of hypertension S. B12 and carnitine after 12 months of administration in patients with diabetic neuropathy T. Hatzitolios, Greece 985 Biological actions of glucagon gene-derived peptides in the peripheral nervous system of mice M. Solini, Italy 986 Cell populations and molecular biomarkers in blood and urine characterise nephropathy in type 1 diabetes P. Eid, Lebanon, Qatar 233 991 Role of gastrointestinal inflammation in diabetic kidney disease M. Rossing, Finland, Denmark 992 Unique synergism between obesity and metabolic syndrome as a risk for incident chronic kidney disease: study in a non-diabetic population K. Aizawa, Japan 993 Association of glucose metabolism and kidney function in middle-aged adults M. Dekkers, Netherlands 994 Euglycaemia in patients with type 1 diabetes after pancreas-kidney transplantation is not a guaranty of complications stabilisation: role of oxidative stress A. Musaeva, Russian Federation 995 Active vitamin D treatment does not modify arterial stiffness and markers of cardio-renal risk in patients with type 2 diabetes and stage 3 chronic kidney disease J. Miyakawa, Japan 1000 the impact of sotagliflozin on renal function, albuminuria, and blood pressure in adults with type 1 diabetes D. Kistorp, Denmark, France 1005 Comparison of renal effects of ezetimibe-statin combination versus statin monotherapy in patients with and without diabetes: a propensity score-matched analysis J. Chan, Cameroon, Colombia, Argentina, Turkey, Mexico, India, Russian Federation, France, China 1007 Renal complication and duration of diabetes: an international comparison in persons with type 1 diabetes A. Dedov, Russian Federation 236 1010 Type 2 diabetes genetic risk score and morbidity and mortality associated with diabetic kidney disease D. Kankova, Czech Republic 1011 High glomerular filtration rate is associated with impaired arterial stiffness and subendocardial viability ratio in prediabetic subjects A. Rabuazzo, Italy 1012 Blood pressure variability and microvascular dysfunction: the Maastricht Study S. Stehouwer, Netherlands 1013 Factors associated with change in estimated glomerular filtration rate differ between people with and those without diabetes: a 24,621 person-year analysis S. Vrang, Denmark 1016 A role for collagen I in regulating connexin-43 mediated hemichannel activity in the proximal region of the diabetic kidney J. San Martin, Chile 1018 Liver X receptors activation triggered autophagy suppression contributes to podocyte injury in vitro and in vivo Z. Li, China 1019 Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogramming M. Koya, Japan 1021 Purinergic receptor (P2X7) activation contributes to disassembly of adherens and tight junctions in tubular epithelial cells of the diabetic kidney G. Schalkwijk, Netherlands 1023 Cocoa intake ameliorates renal damage by modulating the redox status, autophagy and apoptosis in Zucker diabetic fatty rats D. Valverde, Spain 1025 Effect of glucose-lowering agents on diabetic retinopathy in patients with type 2 diabetes: a systematic review and network meta-analysis I. Gautier, France 1027 the relationship of retinal vessel and image texture characteristics to diabetic nephropathy in Chinese patients with type 2 diabetes B. Ji, China 1028 Genome-wide association study for famine-associated diabetic retinopathy O. Lyssenko, Norway, Sweden, Ukraine 1029 HbA1c as a risk factor for retinopathy and nephropathy in persons with type 1 diabetes J. Lind, Sweden 1030 Association of non-diabetic hyperglycaemia and microvascular and macrovascular complications of type 2 diabetes: a retrospective cohort study E. Timonen, Finland 1032 Carotid stiffness is associated with retinal microvascular dysfunction: the Maastricht study T. Stehouwer, Netherlands 1033 Association between pulse wave velocity and the severity of diabetic retinopathy in type 2 diabetes S. Ciudin, Spain 1034 Validation of artificial intelligence eye screening for diabetic retinopathy: analysis from a pivotal multi-centre trial E. Lam, Hong Kong 1037 Evaluating an algorithm for screening intervals for diabetic retinopathy and the effect of HbA1c and hypertension S. Lund-Andersen, Denmark 240 1038 Normal waist circumference identifies type 2 diabetic patients at lower risk of retinopathy L.

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The protagonist leaves his wife and child to seek refuge and opportunity in a foreign land, hoping to establish a new home for his family. The meticulous photo-realistic drawings chart his arrival in a strange land; his inability to interpret indecipherable language, curious customs, the struggle to find work and establish relationships. His personal story is interwoven with the immigration histories of the sympathetic strangers who help him. They have the misfortune to lose their parents and despite their intelligence, charm and resourcefulness they are exceptionally unlucky. This leads to many difficult and dangerous experiences, which inevitably amuse and entertain. This irreverent and twisted tale should prove popular in the classroom and there are several sequels. They seek to use Shakespeare as a vehicle for self-scrutiny and recognition in the Australian community. Authors were asked to compose a story around the painting placed on the postage stamp. Stories range from the chilling horror of First Dance to the joys and disappointments of first love. When the elusive Starkey arrives at the orphanage, Marcel, the proud Nicola, resourceful Bea and combative Fergus are drawn into a plan to steal the Book of Lies to discover who they really are and save the kingdom. Only by undertaking a dangerous journey will the truth be revealed in a final confrontation. This quest narrative combines elements of traditional fantasy, action and adventure in an intriguing and compelling read. As the reader/viewer moves through the book, the rat, a cat and the cow over the moon are all there but they are getting caught up in a different narrative. The Book that Jack Wrote provides a good introduction to narrative structure and allusion. Bruno is immediately disconnected from his new home without friends or his extended family to distract him. Despite being told that the strange-looking camp outside his house is out of bounds, Bruno decides to follow the wire fence to the camp. Excited by the prospect of finding a friend, Bruno returns the next day and almost every day after, meeting at the same spot and talking. Eventually Bruno decides to cross over to the other side of the fence with devastating consequences. The innocence of Bruno and, ultimately, his revelation are effectively captured through the narrative voice. And then the chase is on through the streets of London with the boy, a bear he has released, a freed baron from a prison followed by a very angry bard (Shakespeare). Finally, just as he is about to be caught he races back to the theatre and is transported back to his own time. This wordless picture book contains accurate depictions of the times, with heads on spikes, and is cartoonish in style. Questions about who Nik is and which side he will support make for a riveting tale with harsh lessons and difficult decisions. Year 9 students will relish group discussions on the ethical positions of both sides. Terry Pratchett wrote this book when he was 17 and then rewrote it when he was 43. The film also has an entirely non-professional cast, reinforced by the list of monks in the final credits. Focusing on a particular group of young novice monks in a Buddhist monastery in the Himalayas, whose abbot is patiently awaiting for the day they can all return home to Tibet, it is also set against the backdrop of the World Cup Soccer competition of 1998. The young boys are shown going through the Buddhist rituals and ceremonies as befits their novice status in the monastery, but they are also shown as typical young boys getting up to mischief and playing practical jokes. But juxtaposed with the humour and their unusual perspectives on life, politics and other things such as American consumerism (represented by Coca Cola cans in the film) are the serious insights revealed of their political status and Buddhist teachings. On another world two races exist, the gentle Mystics who teach about peace and love, and the Skeksis, a violent and powerful tribe. Two Gelfings, Jen and Kira, survivors of a race wiped out by the Skeksis, go on a quest to find a shard to heal the Dark Crystal and bring unity back to their world. The Dark Crystal took five years to make and the directors have created a fascinating world with a diversity of creatures and ingenious flora and fauna as well as providing a cathartic and satisfying conclusion. Anne Frank died in Bergen-Belsen concentration camp just three months before her 16th birthday. After her arrest the scattered pages of her diary were collected by a sympathetic secretary working in the building. Students in Years 9 and 10 can empathise with Anne as they explore her descriptions of and reactions to life under the German occupation. Their story is set in Broome and the outbreak of war is about to affect everyone in the town. There is much tension and, as racial intolerance builds, old friendships cannot always survive the strains. Paul, 14 and missing his father, finds his ageing Nonno increasingly embarrassing and exasperating. How can he concentrate on his homework, girls and fast cars when he constantly has to deal with this forgetful, annoying old man. The thylacine yearns for his freedom but falls mute as he faces despair, dreaming of freedom in the landscape, depicted in beautiful double-page colour spreads that contrast with the monochromatic cages the thylacine is surrounded by. This book would work in any classroom studying the power of verbal and visual images or learning about how to create a voice. After a violent storm destroys his town and beloved books, Morris is led by a mysterious lady to a vibrant household of books which come alive.

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If anything, the discussion of theories and research indicates that instead of ignoring motivation, managers must take an active role in motivating their employees. If performance needs to be im proved, then managers should intervene and help create an atmosphere that encourages, supports, and sustains improvement. Managers must remember that ability, competence, and opportunity all play a role in motivation. A person with little ability or few skills will have a difficult time being productive. Some individuals practice a high degree of self-regulation and personal motivation. Social learning occurs on a regular basis, and managers must be aware that their style, techniques, and work behavior are being observed and can be easily imitated. When employees note that valued outcomes can be achieved through performance, a major part of the motivation strategy has succeeded. Establishing moderately difficult goals to direct behavior is an important part of any motivational program. Managers should try to provide employees with jobs that offer equity, task challenge, variety, and opportunities for need satisfaction. If motivation is to be energized, sustained, and directed, managers have to understand needs, intentions, preferences, goals, reinforcement, and comparison. Failure to learn about these con cepts results in many missed opportunities to motivate employees in a positive manner. Ratings are based on available empirical research conducted in organizations primarily in the United States and Canada. Ratings also use the judgments of researchers, anecdotal information, and managerial opinions. The knowledge and insight provided by summarizing theories, empirical studies, and opinions can provide the basis for developing motivational reward programs. Organizational Reward Systems Managers who understand and are comfortable with a number of motivational approaches are better prepared to design effective and motivational reward programs. Theories set the tone and the direction of how to create a motivational atmosphere. Applying the theoretical principles to the work environment is what an organizational reward system attempts to accomplish. Numerous changes are taking place in how performance is evaluated and rewards are distributed. Requests to eliminate piece rate incentive systems,71 convert all reward systems to group-based approaches, shift risk from employers to employees by making a greater per centage of compensation variable in nature. Although parts of each suggestion have some validity, such radical proposals are unlikely to influence the majority of managers. Instead of radical changes and across-the-board debunking, pro gressive approaches are likely to draw more attention. Pay systems based on competencies and contributions made, team-based incentives, and rewards focusing on improved results are becoming more widely considered and implemented systems. As organizations become more involved in global transactions, business pay and rewards will be more closely linked to over all unit and total company results. To the extent that rewards are adequate and equitable, the individual achieves a level of satisfaction. A significant amount of research has been done on what determines whether individuals are satisfied with rewards. Edward Lawler has summarized five conclusions based on the behavioral science research literature:73 1. Satisfaction with a reward is a function of both how much is received and how much the individual feels should be received. Extrinsic rewards are external to the work itself; they are administered externally. People differ in the rewards they desire and in the relative importance different rewards have for them. Money is a reward that leads to such things as prestige, autonomy, security, and shelter. In fact, there are those who including makeshift remedies to ensure that she never believe that many of our management and leadership models found out any problems existed. To the group, their inability are culture-bound; that is, they do not consider the possibility to handle equipment problems meant losing face. There are also those who believe that national cul managers need to be careful regarding how they reward tural differences are overstated. If American expatriate managers were to transfer rewards such as salary, salary increases, and individual, this tradition of reward to China, they would be very team and organizational performance incentives; whereas surprised at the outcome. As a result, they may feel reluctant to ask for rewards have made mistakes in the past in their assumptions about and may also be less likely to complain or ask questions. The manager assumed that by delegating this in Trying Times (San Francisco: Jossey-Bass, 1993). But there are important considerations that managers can use to develop and distribute rewards. Federal legislation, union contracts, and managerial fairness have provided at least minimal rewards in most work settings. Unless individual differences are considered, the reward process invariably is less effective than de sired. Extrinsic Rewards external to the rewards are rewards external to the job, such as pay, promotion, or fringe benefits; intrinsic job, such as pay, rewards are those that are part of the job itself, such as the responsibility, challenge, and promotion, or fringe feedback characteristics of the job.


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  • https://www.cdha.ca/pdfs/Profession/Journal/v43n2.pdf
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  • https://ocw.mit.edu/courses/health-sciences-and-technology/hst-151-principles-of-pharmacology-spring-2005/lecture-notes/ln2425_antimic.pdf
  • http://clinicalevidence.pbworks.com/w/file/fetch/64147467/AB%20PROFILACTICOS.pdf

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